---
title: "Advanced RNA Modifiers Reagents: See the Full List"
description: kbDNA offers RNA modifications for better maintenance and protection against degradation. We use advanced RNA modifiers equipped with affinity and fluorescent labels.
image: https://app.kbdna.com/hubfs/Imported_Blog_Media/RNA%20Modifiers%201-1920w-1.png
---

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 Nov 25, 2017, 12:00:00 AM

# Advanced RNA Modifiers Reagents: See the Full List

[L L](https://app.kbdna.com/blog/author/l-l)

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![Advanced RNA Modifier Reagents: See the Full List](https://app.kbdna.com/hubfs/Imported_Blog_Media/RNA%20Modifiers%201-1920w-1.png)

## RNA Modifiers

See the full list of in-house RNA Modifiers used in our synthesis

### Optimized Nucleotide Synthesis

While most modifications to RNA are built for maintenance, demand in new and improved compounds is growing for various use of synthetic RNA. A major one is gRNA for recent CRISPR/CAS9 systems, but the more veteran application for RNA modifiers is undoubtedly [antisense RNA](https://app.kbdna.com/nucleotide-synthesis). In order to harness the mechanistic advantages of RNA interference, custom nucleotide sequences need to be equipped with the ability to permeate cell walls, bind to the target and protect itself from degradation. We offer an advanced selection of 2’-O-alkyl/methyl compounds along with affinity and fluorescent labels to follow a sequence in experiments all throughout its development.

![](https://app.kbdna.com/hubfs/Imported_Blog_Media/RNA%20Modifiers%202-1920w-1.jpg)

### RNA Synthesis/Modifiers & Labelling

| Modifiers |
| --- |
| N 3 -Methyl-uridine-DMTr-3'-Icaa CPG |
| N 3 -Thiobenzoylethyl-uridine-DMTr-3'-Icaa CPG |
| N 4 -Ethyl-cytidine-DMTr-3'-Icaa CPG |
| N 6 -Benzyl-adenosine-DMTr-3'-Icaa CPG |
| N 6 -Isopentenyl-adenosine-DMTr-3'-Icaa CPG |
| Pseudo-uridine-DMTr-3'-Icaa CPG |
| Purine-riboside-DMTr-3'-Icaa CPG |
| Thymidine-DMTr-3'-Icaa CPG |
| Uridine-DMTr-3'-Icaa CPG |
| β -L- Thymidine-DMTr-3'-Icaa CPG |
| β -L-Adenosine ( N -Bz)-DMTr 3'-Icaa CPG |
| β -L-Cytidine ( N -Ac)-DMTr 3'-Icaa CPG |
| β -L-Cytidine ( N -Bz)-DMTr 3'-Icaa CPG |
| β -L-Guanosine ( N -iBu)-DMTr 3'-Icaa CPG |
| β -L-Uridine-DMTr 3'-Icaa CPG |
| (2)-Amino (TFA) Protected RNA 3'-CPG |
| 2-Amino-2'-amino (TFA)-uridine-DMTr-3'-Icaa CPG |
| 2'-Amino (TFA)-cytidine ( N -Bz) CPG |
| Puromycin Supports |
| 3'-L- O -Methyl-tyrosine-puromycin-2'- Icaa CPG |
| Puromycin 2'-succinyl Icaa CPG |
| RNA Synthesis: Purification Kit |
| Anhydrous Ammonia in Ethanol Solution (20% ammonia by wt in absolute ethanol) |
| Fluoride Ion Removal Solution |
| Tetra butyl Ammonium Fluoride (1 M Sol in THF) |
| Levulinyl Deprotection Solution |
| Levulinyl Deprotection Solution |
| O-Alkyl & Antisenses Oligonucleotide Modifications |

### 2'- O -Methyl-RNA Synthesis

| A: CE Phosphoramidites (RNA synthesis) |
| --- |
| (1)-2'-O-Me RNA Phosphoramidites |
| 2'- O -Methyl-adenosine ( N -Bz)-DMTr-3'-CEP |
| 2'- O -Methyl-adenosine ( N -Bz)-MMTr-3'-CEP |
| 2'- O -Methyl-cytidine ( N -Ac)-DMTr-3'-CEP |
| 2'- O -Methyl-cytidine ( N -Bz)-DMTr-3'-CEP |
| 2'- O -Methyl-guanosine ( N -iBu)-DMTr-3'-CEP |
| 2'- O -Methyl-guanosine ( N -iBu)-MMTr-3'-CEP |
| 2'- O -Methyl-uridine-DMTr-3'-CEP |
| (2)-2'-O-Me RNA Phosphoramidites (mild protection) |
| 2'- O -Methyl-adenosine ( N -PAC)-DMTr-3'-CEP |
| 2'- O -Methyl-cytidine ( N -Ac)-DMTr-3'-CEP |
| 2'- O -Methyl-cytidine ( N -PAC)-DMTr-3'-CEP |
| 2'- O -Methyl-guanosine ( N -DMF)-DMTr-3'-CEP |
| 2'- O -Methyl-guanosine ( N -iPrPAC)-DMTr-3'-CEP |
| 2'- O -Methyl-guanosine ( N -PAC)-DMTr-3'-CEP |
| 2'- O -Methyl-uridine-DMTr-3'-CEP |

| B: Minor 2'-O-Me-RNA Phosphoramidites |
| --- |
| 2'- O -Methyl-5-propynyl-uridine-DMTr-3'-CEP |
| 2'- O -Methyl-uridine (C-6)-DMTr-3'-CEP (Amino Modifier)\\" |
| 2'- O -Methyl-2,6-diamino-purine ( N 2, N 6-diPAC)-DMTr-3'-CEP |
| 2'- O -Methyl-4-triazolyl-uridine-DMTr-3'-CEP |
| 2'- O -Methyl-5-bromo-uridine-DMTr-3'-CEP |
| 2'- O -Methyl-5-iodo-uridine-DMTr-3'-CEP |
| 2'- O -Methyl-5-methyl-cytidine ( N -Ac)-DMTr-3'-CEP |
| 2'- O -Methyl-5-methyl-cytidine ( N -Bz)-DMTr-3'-CEP |
| 2'-O-Methyl-5-methyl-cytidine ( N -DMF)-DMTr-3'-CEP |
| 2'- O -Methyl-5-methyl-uridine (Ribo Thymidine)-DMTr-3'-CEP |
| 2'- O -Methyl-5-propynyl-cytidine ( N -Bz)-DMTr-3'-CE |
| 2'- O -Methyl-7-deaza 7-iodo-adenosine ( N -Bz)-DMTr-3'-CEP |
| 2'- O -Methyl-7-deaza 7-Iodo-guanosine ( N -iBu)-DMTr-3'-CEP |
| 2'- O -Methyl-7-deaza-7-propargyl (Amino- TFA)-guanosine ( N -iBu)-DMTr-3'-CEP |
| 2'- O -Methyl-7-deaza-7-propargyl(Amino-TFA)-adenosine ( N -Bz)-DMTr-3'-CEP |
| 2'- O -Methyl-7-deaza-adenosine ( N -Bz)-DMTr-3'-CEP |
| 2'- O -Methyl-7-deaza-guanosine ( N -iBu)-DMTr-3'-CEP |
| 2'- O -Methyl-cytidine ( N -DMF)-DMTr-3'-CEP (Amino Modifier) |
| 2'- O -Methyl-Inosine-DMTr-3'-CEP |

| C-Backbone 2'-O-Me-RNA modificatios |
| --- |
| (1)- P-O -Ethyl Phosphoramidites |
| 2'- O -Methyl- P-O -ethyl-adenosine ( N -Bz)-DMTr-3'-CEP |
| 2'- O -Methyl- P-O -ethyl-adenosine ( N -PAC)-DMTr-3'-CEP |
| 2'- O -Methyl- P-O -ethyl-cytidine ( N -Bz)-DMTr-3'-CEP |
| 2'- O -Methyl- P-O -ethyl-cytidine ( N -PAC)-DMTr-3'-CEP |
| 2'- O -Methyl- P-O -ethyl-guanosine ( N -iBu)-DMTr-3'-CEP |
| 2'- O -Methyl- P-O -ethyl-guanosine ( N -PAC)-DMTr-3'-CEP |
| 2'- O -Methyl- P-O- ethyl-thymidine-DMTr-3'-CEP |
| 2'- O -Methyl- P-O- ethyl-uridine-DMTr-3'-CEP |
| (2)-Methyl RNA Phosphoramidites |
| 2'- O -Methyl- P -methyl-adenosine ( N -Bz)-DMTr-3'-CEP |
| 2'- O -Methyl- P -methyl-cytidine ( N -Ac)-DMTr-3'-CEP |
| 2'- O -Methyl- P -methyl-cytidine ( N -iBu)-DMTr-3'-CEP |
| 2'- O -Methyl- P -methyl-guanosine ( N -iBu)-DMTr-3'-CEP |
| 2'- O -Methyl- P -methyl-uridine-DMTr-3'-CEP |

| D: Supports For 2'-OME RNA Synthesis |
| --- |
| (1)-2'-OMe-RNA 3'-CPG |
| 2'- O -Methyl-adenosine ( N -Bz)-DMTr-3'-Icaa CPG |
| 2'- O -Methyl-cytidine ( N -Ac)-DMTr-3'-Icaa CPG |
| 2'- O -Methyl-cytidine ( N -Bz)-DMTr-3'-Icaa CPG |
| 2'- O -Methyl-guanosine ( N -DMF)-MMTr-3'-Icaa CPG |
| 2'- O -Methyl-guanosine ( N -iBu)-DMTr-3'-Icaa CPG |
| 2'- O -Methyl-uridine-DMTr-3'-Icaa CPG |
| (2)-2'-OMe-RNA 3'-CPG (mild protection) |
| 2'- O -Methyl-adenosine ( N -PAC)-DMTr-3'-Icaa CPG |
| 2'- O -Methyl-cytidine ( N -Ac)-DMTr-3'-Icaa CPG |
| 2'- O -Methyl-cytidine ( N -PAC)-DMTr-3'-Icaa CPG |
| 2'- O -Methyl-guanosine ( N -PAC)-DMTr-3'-Icaa CPG |
| (3)-Minor 2'-OMe-RNA 3'-CPG |
| 2'- O -Methyl-5-methyl-cytidine ( N -DMF)-DMTr-3'-Icaa CPG |
| 2'- O -Methyl-5-bromo-uridine-DMTr-3'-Icaa CPG |
| 2'- O -Methyl-5-iodo-uridine-DMTr-3'-Icaa CPG |
| 2'- O -Methyl-5-methyl-cytidine ( N -Bz)-DMTr-3'-Icaa CPG |
| 2'- O -Methyl-inosine-DMTr-3'-Icaa CPG |
| 2'- O -Methyl-thymidine-DMTr-3'-Icaa CPG |

### 2'-O-Me 5'→ 3' RNA Synthesis

| A: 2'-O-Me 5'-CE RNA Phosphoramidites |
| --- |
| 2'- O -Methyl-adenosine ( N -Bz)-DMTr-5'-CEP |
| 2'- O -Methyl 5-methyl-uridine-DMTr-5'-CEP |
| 2'- O -Methyl-5-methyl-cytidine ( N -Bz)-DMTr-5'-CEP |
| 2'- O -Methyl-cytidine ( N -Ac)-DMTr-5'-CEP |
| 2'- O -Methyl-cytidine ( N -Bz)-DMTr-5'-CEP |
| 2'- O -Methyl-guanosine ( N -iBu)-DMTr-5'-CEP |
| 2'- O -Methyl-uridine-DMTr-5'-CEP |

| B: Support:2'-O-Me 5'-CPG |
| --- |
| 2'- O -Methyl-5-methyl-cytidine ( N -Bz)-DMTr-5'-Icaa CPG |
| 2'- O -Methyl-5-methyl-uridine-DMTr-5'-Icaa CPG |
| 2'- O -Methyl-adenosine ( N -Bz)-DMTr-5'-Icaa CPG |
| 2'- O -Methyl-cytidine ( N -Ac)-DMTr-5'-Icaa CPG |
| 2'- O -Methyl-cytidine ( N -Bz)-DMTr-5'-Icaa CPG |
| 2'- O -Methyl-guanosine ( N -iBu)-DMTr-5'-Icaa CPG |
| 2'- O -Methyl-uridine-DMTr-5'-Icaa CPG |

### 2'-F RNA Synthesis

| A: CE Phosphoramidites |
| --- |
| (1)-2'-F-RNA Monomers |
| 2'-Fluoro-2'-deoxyadenosine ( N -DMF)-DMTr-3'-CEP |
| 2'-Fluoro-2'-deoxyadenosine ( N -Bz)-DMTr-3'-CEP |
| 2'-Fluoro-2'-deoxycytidine ( N -Ac)-DMTr-3'-CEP |
| 2'-Fluoro-2'-deoxyguanosine ( N -DMF)-DMTr-3'-CEP |
| 2'-Fluoro-2'-deoxyguanosine ( N -iBu)-DMTr-3'-CEP |
| 2'-Fluoro-2'-deoxyuridine-DMTr-3'-CEP |
| (2)-2'-F-RNA Monomers (Ultramild) |
| 2'-Fluoro-2'-deoxyadenosine ( N -PAC)-DMTr-3'-CEP |
| 2'-Fluoro-2'-deoxycytidine ( N -Ac)-DMTr-5'-CEP |
| 2'-Fluoro-2'-deoxyguanosine ( N -iPrPAC)-DMTr-3'-CEP |
| 2'-Fluoro-2'-deoxyuridine-DMTr-5'-CEP |

| B: Minor 2'-F-RNA Monomers |
| --- |
| 2'-Fluoro-2'-deoxyinosine-DMTr-3'-CEP |
| 2'-Fluoro-5-iodo-2'-deoxyuridine-DMTr-3'-CEP |
| 2'-Fluoro-5-methyl-2'-deoxycytidine ( N -Ac)-DMTr-3'-CEP |
| 2'-Fluoro-5-methyl-2'-deoxycytidine ( N -Bz)-DMTr-3'-CEP |
| 2'-Fluoro-5-methyl-2'-deoxyuridine-DMTr-3'-CEP |

| C: Supports |
| --- |
| (1)-Support-3'-CPG |
| 2'-Fluoro-2'-deoxyadenosine ( N -DMF)-DMTr-3'-Icaa CPG |
| 2'-Fluoro-2'-deoxyadenosine ( N -Bz)-DMTr-3'-Icaa CPG |
| 2'-Fluoro-2'-deoxycytidine ( N -Ac)-DMTr-3'-Icaa CPG |
| 2'-Fluoro-2'-deoxyguanosine ( N -DMF)-DMTr-3'-Icaa CPG |
| 2'-Fluoro-2'-deoxyguanosine ( N -iBu)-DMTr-3'-Icaa CPG |
| 2'-Fluoro-2'-deoxyuridine-DMTr-3'-Icaa CPG |

### 2'- O -Butyne RNA Synthesis

| A: 2'-O-Butyne-RNA Phosphonamidites |
| --- |
| 2'- O -Butyne-aenosine ( N -Bz)-DMTr 3'-CEP |
| 2'- O -Butyne-cytidine ( N -Bz)-DMTr-3'-CEP |
| 2'- O -Butyne-guanosine ( N -iBu)-DMTr-3'-CEP |
| 2'- O -Butyne-uridine-DMTr-3'-CEP |

| B: Supports: 2'-O-Butyne-RNA 3'-CPG |
| --- |
| 2'- O -Butyne-adenosine ( N -Bz)-DMTr-3'-Icaa CPG |
| 2'- O -Butyne-cytidine ( N -Bz)-DMTr-3'-Icaa CPG |
| 2'- O -Butyne-guanosine ( N -iBu)-DMTr-3'-Icaa CPG |
| 2'- O -Butyne-uridine-DMTr-3'-Icaa CPG |

### RNA: 2'- O -Propargyl RNA Synthesis (Combiclick TM Chemistry)

| A: 2'- O -Propargyl RNA Phosphoramidites |
| --- |
| 2'- O -Propargyl-adenosine ( N -Bz)-DMTr-3'-CEP |
| 2'- O -Propargyl-cytidine ( N -Ac)-DMTr-3'-CEP |
| 2'- O -Propargyl-cytidine ( N -Bz)-DMTr-3'-CEP |
| 2'- O -Propargyl-guanosine ( N -iBu)-DMTr-3'-CEP |
| 2'- O -Propargyl-inosine-DMTr-3'-CEP |
| 2'- O -Propargyl-uridine-DMTr-3'-CEP |

| B: 2'-O-Propargyl RNA:Minor Phosphoramidites |
| --- |
| 2'- O -Propargyl-abasic-DMTr-3’-CEP; 2'- O -Propargyl-1,1 dihydro-β-D-ribose-DMTr-3’-CEP |
| 2'- O -Propargyl-abasic-DMTr-3’-Icaa CPG |
| Ara-Propargyl-inosine-DMTr-3’-CEP |

| C: Supports-2'-O-Propargyl RNA 3'-CPG |
| --- |
| 2'- O -Propargyl-adenosine ( N -Bz) DMTr 3'-Icaa CPG |
| 2'- O -Propargyl-cytidine ( N -Ac) DMTr 3'-Icaa CPG |
| 2'- O -Propargyl-cytidine ( N -Bz) DMTr 3'-Icaa CPG |
| 2'- O -Propargyl-guanosine ( N -iBu) DMTr 3'-Icaa CPG |
| 2'- O -Propargyl-inosine DMTr 3'-Icaa CPG |
| 2'- O -Propargyl-uridine DMTr 3'-Icaa CPG |

### RNA: 2'-O-Hexyne RNA Synthesis

| A: 2'-O-Hexyne RNA Phosphoramidites |
| --- |
| 2'- O -Hexyne-inosine-DMTr-3’-CEP |
| 2'- O -Hexyne-1,1 dihydro-β-D-ribose-DMTr-3’-CEP |

### RNA: 3'-O-Alkyl RNA Synthesis

| A: 3'- O -Alkyl RNA phosphoramidites |
| --- |
| (1)-3'- O -Methyl-RNA Phosphoramidites |
| 3'- O -Methyl-adenosine ( N -Bz)-DMTr-2'-CEP |
| 3'- O -Methyl-cytidine ( N -Ac)-DMTr-2'-CEP |
| 3'- O -Methyl-cytidine ( N -Bz)-DMTr-2'-CEP |
| 3'- O -Methyl-guanosine ( N -iBu)-DMTr-2'-CEP |
| 3'- O -Methyl-inosine-DMTr-2'-CEP |
| 3'- O -Methyl-thymidine-DMTr-2'-CEP |
| 3'- O -Methyl-uridine-DMTr-2'-CEP |
| (2)-3'-O-Propargyl RNA Phosphoramidites |
| 3'- O -Propargy-cytidine ( N -Ac)-DMTr-2'-CEP |
| 3'- O -Propargyl-adenosine ( N -Bz)-DMTr-2'-CEP |
| 3'- O -Propargyl-cytidine ( N -Bz)-DMTr-2'-CEP |
| 3'- O -Propargyl-guanosine ( N -iBu)-DMTr-2'-CEP |
| 3'- O -Propargyl-uridine-DMTr-2'-CEP |

| B: 3'-O-Alkyl RNA Supports |
| --- |
| (1)-Supports:3'- O -ME-RNA 2'-CPG |
| 3'- O -Methyl-adenosine ( N -Bz)-DMTr-2'-Icaa CPG |
| 3'- O -Methyl-cytidine ( N -Bz)-DMTr-2'-Icaa CPG |
| 3'- O -Methyl-guanosine ( N -iBu)-DMTr-2'-Icaa CPG |
| 3'- O -Methyl-inosine-DMTr-2'-Icaa CPG |
| 3'- O -Methyl-uridine-DMTr-2'-Icaa CPG |
| (2)-Supports:3'-O-Propargyl RNA 2'-CPG |
| 3'- O -Propargyl-adenosine ( N -Bz)-DMTr-2'-Icaa CPG |
| 3'- O -Propargyl-cytidine ( N -Ac)-DMTr-2'-Icaa CPG |
| 3'- O -Propargyl-cytidine ( N -Bz)-DMTr-2'-Icaa CPG |
| 3'- O -Propargyl-guanosine ( N -iBu)-DMTr-2'-Icaa CPG |
| 3'- O -Propargyl-uridine-DMTr-2'-Icaa CPG |

[< Older Post](https://app.kbdna.com/resource-library/reagents-for-nucleic-acid-chemistry) [Newer Post >](https://app.kbdna.com/resource-library/compounds-for-rna-synthesis)

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